Stone Fish venom

Stonefish venom: some biochemical

Stonefish venom: some

Stonefish venom: some

Stonefish venom has been fractionated on carboxymethyl cellulose and Sephadex columns; of the fractions obtained only one was toxic to rats. The active fraction contained a relatively high proportion of aromatic amino acids. Whole venom was examined for enzyme activity and enzyme inhibition; the only significant activity found was that of hyaluronidase.Stonefish venom: some The venom also caused a marked increase in capillary permeability. Ultracentrifuge measurements suggest that the toxic material has a molecular weight of the order of 150,000.

Stonefish venom: some

this method yielded minute amounts of the lethal factor and, therefore, it could not be characterized further. Earlier, Austin et al. (1965) had achieved a partial purification of the iethal factor by CM-cellulose and Sephadex G-75 chromatography. The partiaily-purified lethal factor was reported to be insoluble in deionized water. …

Stonefish venom: some

… High performance permeation gel chromatography of SNTX produced a single protein peak of molecular weight 148,000. This is consistent with a value of 150,000 and sedimentation coefficient of 8.f9.0 obtained for the lethal fraction (undetermined purity) from the venom of S. trachynis and S. t’errucosa (Austin et al., 1965). The pI of SNTX, determined by using the crude venom and assayed by lethality test, was 6.9. ….. Studies on the enzyme activity of stonefish venoms are rather limited. An early study was reported by Austin et al . (1965) and, almost three decades later, a more detailed investigation was carried out by Khoo et al. (1992\. 3.3.1. Hyaluroniclase Austin et al. (1965) detected hyaluronidase activity in the venoms of S. horrida and S. L)errucose, but did not report the level ofactivity. Subsequently. Khoo et al. (1992) purified and characterized theactivityof …

Stonefish venom: some

… Stonefish are usually sluggish and will not attack a human being unless the dorsal spines are trampled upon [5]. As a result of stone fish envenomation injuries symptoms appeared to be; respiratory difficulty due to pulmonary oe- dema, hypotension, bradycardia, arrhythmia, cardio- vascular collapse, muscle weakness, paralysis con- vulsion and death at severe injuries [8,5,6].

Stonefish venom: some

Respir- atory system composed of; the conducting tract (tra- chea, bronchi and bronchioles) and the respiratory zone (respiratory bronchioles, alveolar ducts, and al- veoli), and gas exchanging is the main function of lungs [9].The alveolus is the functional and structural component of the respira- tory zone [9]. As respiratory system is vital organ and being affected with toxins, the current study aimed to evaluate the toxicity of stonefish venom on lungs, using histological and biochemical ap- proaches based on [5,8,9,11]. …

Stonefish venom: some

… Clinical signs and symptoms of stone fish sting and venom such as redness and swelling in sting site, followed by shock, respiratory distress due to pulmonary edema, hypotension and bradycardia, fever, and muscle weakness have been observed. In severe cases, delirium, general- ized paralysis, convulsions, cardiovascular collapse, and occasion- ally death have been reported (Saunders et al., 1962;Austin et al., 1965;Gwee et al., 1994;Sutherland and Tibballs, 2001;Haddad et al., 2003;Lee et al., 2004). …

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