Bee Venom

neurodegenerative diseases

Honey Bee venom

Bee Venom (BV) has long been used in Korea to relieve pain symptoms and to treat inflammatory diseases, such as rheumatoid arthritis.Honey Bee venom The underlying mechanisms of the anti-inflammatory and analgesic actions of BV have been proved to some extent. Additionally, recent clinical and experimental studies have demonstrated that BV and BV-derived active components are applicable to a wide range of immunological and neurodegenerative diseases, including autoimmune diseases and Parkinson’s disease.

نتیجه تصویری برای ‪bee‬‏

These effects of BV are known to be mediated by modulating immune cells in the periphery, and glial cells and neurons in the central nervous system. This review will introduce the scientific evidence of the therapeutic effects of BV and its components on several immunological and neurological diseases, and describe their detailed mechanisms involved in regulating various immune responses and pathological changes in glia and neurons.

Honey Bee venom

Bee Venom (BV) therapy is a form of medicine originated from the ancient Greece and China.Honey Bee venom 1 Several scientific reports suggesting the anti-rheumatic and anti-inflammatory effects of BV have been published for a hundred years [1,2].

تصویر مرتبط

Honey Bee venom

In Korea, BV has long been used to relieve pain and to treat various diseases, such as arthritis, rheumatism, herniation nucleus pulpous, cancer, asthma, and skin diseases [3,4,5]. It is administered systemically or in the form of chemical stimulation of acupoints, so called “BV acupuncture” or “apipuncture”. BV is known to contain many active components, including peptides (e.g., melittin and apamin), enzymes (e.g., phospholipase A2 (PLA2)), and small molecules (e.g., histamine). Recent studies suggested further that BV and BV-derived active components might have potent therapeutic effects on refractory immunological and neurodegenerative diseases including allergic disorders, autoimmune diseases, amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD) [3,6,7,8,9], however well-controlled, randomized clinical studies are still insufficient.

Honey Bee venom

Bee Venom (BV) therapy is a form of medicine originated from the ancient Greece and China. Several scientific reports suggesting the anti-rheumatic and anti-inflammatory effects of BV have been published for a hundred years [1,2].

نتیجه تصویری برای ‪bee‬‏

In Korea, BV has long been used to relieve pain and to treat various diseases, such as arthritis, rheumatism, herniation nucleus pulpous, cancer, asthma, and skin diseases [3,4,5]. It is administered systemically or in the form of chemical stimulation of acupoints, so called “BV acupuncture” or “apipuncture”. BV is known to contain many active components, including peptides (e.g., melittin and apamin), enzymes (e.g., phospholipase A2 (PLA2)), and small molecules (e.g., histamine). Recent studies suggested further that BV and BV-derived active components might have potent therapeutic effects on refractory immunological and neurodegenerative diseases including allergic disorders, autoimmune diseases, amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD) [3,6,7,8,9], however well-controlled, randomized clinical studies are still insufficient.

Honey Bee venom

Bee venom is safe for most people when injected under the skin by a trained medical professional. Some people might get redness and swelling where the injection is given. Side effects include itching, anxiety, trouble breathing, chest tightness, heart palpitations, dizziness, nausea, vomiting, diarrhea, sleepiness, confusion, fainting, and low blood pressure.

نتیجه تصویری برای ‪bee‬‏

Side effects are more common in people with the worst allergies to bee stings, in people treated with honeybee venom, and in women.

Live bee stings have been safely administered under medical supervision in doses up to 20 bee stings three times weekly for up to 24 weeks.

Honey Bee venom

Bee venom (BV) is a complex mixture of proteins and contains proteins such as phospholipase and melittin, which have an effect on blood clotting and blood clots. The mechanism of action of honey bee venom (HBV, Apis mellifera) on human plasma proteins and its anti-thrombotic effect were studied. The purpose of this study was to investigate the anti-coagulation effect of BV and its effects on blood coagulation and purification.

Honey Bee venom 1

Crude venom obtained from Apis mellifera was selected. The anti-coagulation factor of the crude venom from this species was purified by using gel filtration chromatography (sephadex G-50), and the molecular weights of the anti-coagulants in this venom estimated by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Blood samples were obtained from 10 rabbits, and the prothrombin time (PT) and the partial thromboplastin time (PTT) tests were conducted. The approximate lethal dose (LD) values of BV were determined.

Honey Bee venom

Crude BV increased the blood clotting time. For BV concentrations from 1 to 4 mg/mL, clotting was not observed even at more than 300 seconds, standard deviations (SDs) = ± 0.71; however, clotting was observed in the control group 13.8 s, SDs = ± 0.52. Thus, BV can be considered as containing anti-coagulation factors. Crude BV is composed 4 protein bands with molecular weights of 3, 15, 20 and 41 kilodalton (kDa), respectively. The LD50 of the crude BV was found to be 177.8 μg/mouse.

Honey bee venom (HBV, Apis mellifera) is a bitter, colorless liquid, and its active portion contains a mixture of proteins that, cause local inflammation and act as anti-coagulants. HBV is a complex mixture of enzymes and polypeptides with low molecular weights, and it has been reported to contain the enzymes phospholipase A2 (PLA2), hyaluronidase, phosphomonoesterase acid esterase, α-D-glucosidase, lysopphospholipase, α-galactosidase, α-acetylamino-deosiglucosidase and arylamidase. The compositions of fresh and dried bee venom (BV) differ mainly in regards to the volatile components; however, the overall biological activities are similar.

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